产品货号：
Z12053
中文名称：
BRSK1抗体
英文名称：
Anti-BRSK1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BRSK1 Antibody |
| 指标别名 | BR serine/threonine kinase 1;BRSK1;KIAA1811;SAD1;SAD1 kinase |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | BRSK1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human BRSK1 recombinant protein (Position:E269-E321). |
| 实际分子量 | 90KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene.BRSK1 was initially identified as a mammalian homolog to the fission yeast S.pombe Cdr2,a mitosis-regulatory kinase and also shows significant homology to the C.elegans neuronal cell polarity regulator SAD1.BRSK1 is unbiquitously expressed,with highest levels of expression in the brain and testes.Similar to its yeast homolog,BRSK1 is thought to be involved in stress-induced cell cycle arrest.Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA,indicating its role in DNA damage checkpoint function.More recently,it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization.While BRSK1- and BRSK2-null mice were viable,double-mutant mice died within two hours of birth.Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites.These neurites also displayed both axonal and dendritic markers.At least two isoforms of BRSK1 are known to exist. |
| Uniprot ID | Q8TDC3 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | BR serine/threonine kinase 1 |
| 蛋白名全称 | Serine/threonine-protein kinase BRSK1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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